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Disturbances of acetylcholine metabolism have already been detected during the Advert individual brains with increased levels of AChE expression in decomposition of acetylcholine and deterioration in action of choline acetyltransferase (ChAT), an enzyme which happens to be responsible for the synthesis of acetylcholine [7,eight,9].
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On the other hand, the molecular biology research has resulted in the availability of amino acid sequence knowledge based on the cloning and cDNA sequencing of genes [140].
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